By National Research Council, Division on Earth and Life Studies, Board on Environmental Studies and Toxicology, Committee on Toxicology, Subcommittee on Acute Exposure Guideline Levels
Document from the Subcommittee on Acute publicity guide degrees and the Committee on Toxicology from the Board on Environmental reports and Toxicology. quantity 2. Softcover.
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Extra info for Acute Exposure Guideline Levels for Selected Airborne Chemicals: Volume 2
35 ppm. The above described conditions produced no intoxication or adverse effects on lung function. In another factory, use of a phosgene indicator badge revealed an average of 34 phosgene exposures per year during the period from 1978 to 1988 (Kaerkes 1992). The workforce contained approximately 200 individuals ranging in age from <20 to 60 y. Exposure concentrations ranged from <50 to 300 ppm·min. Below 50 ppm·min, no signs or symptoms of phosgene toxicity were observed in 75 of 88 individuals; however, three cases of temporary pulmonary edema were observed.
Please use the print version of this publication as the authoritative version for attribution. APPENDIX 39 creased toward control values, achieving 3% below controls on day 14. Food consumption was also decreased compared with controls but was less than 10% below normal by day 4. Lung weights of exposed animals were 60% greater than controls immediately after exposure and remained elevated through day 7 postexposure. Lung nonprotein sulfhydryl (NPSH) content was similar in control and exposed rats on day 1, had increased to 80% above controls on day 2, and decreased back to control levels by day 7.
These less-than-adequate studies are summarized in Table 1–8. 4. Rabbits As was the case with guinea pigs, the few acute lethality studies of phosgene in rabbits do not contain experimental details such as strain or gender, number of animals exposed, or analytical methodology. These less than adequate studies are summarized in Table 1–9. 5. 8 ppm for 470 min. A 1-min LC50 of 1,482 ppm was reported by Moor and Gates (1946), and a 15-min LC50 of 80 ppm was reported by Underhill (1920). No About this PDF file: This new digital representation of the original work has been recomposed from XML files created from the original paper book, not from the original typesetting files.