Download AIDS and Tuberculosis: A Deadly Liaison by Stefan H. E. Kaufmann, Bruce D. Walker PDF

By Stefan H. E. Kaufmann, Bruce D. Walker

Supplying the newest details on preventive, diagnostic and healing points of tuberculosis and AIDS, this is often the single ebook to put a big emphasis at the expanding coexistence of those life-threatening ailments in individuals.
Edited through remarkable scientists within the box, this prepared reference is split into 3 major sections masking immunology and vaccination suggestions, medicines, and scientific issues.
well timed interpreting for microbiologists, virologists, bacteriologists, immunologists, and pathophysiologists, in addition to for the pharmaceutical and biotechnological industries.

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J. , 75, 11983–11991. M. D. (2004) Persistent recognition of j21 j 1 HIV Immunology and Prospects for Vaccines 22 24 25 26 27 autologous virus by high-avidity CD8 T cells in chronic, progressive human immunodeficiency virus type 1 infection. J. , 78, 630–641. , Altfeld, M. D. (2003) Comprehensive epitope analysis of human immunodeficiency virus type 1 (HIV-1)-specific T-cell responses directed against the entire expressed HIV-1 genome demonstrate broadly directed responses, but no correlation to viral load.

1999) HIV-1-specific CD4 þ T cells are detectable in most individuals with active HIV-1 infection, but decline 51 52 53 54 55 56 57 58 59 with prolonged viral suppression. Nat. , 5, 518–525. A. D. (1997) Vigorous HIV-1-specific CD4 þ T cell responses associated with control of viremia. Science, 278, 1447–1450. , Martin, M. and Roederer, M. (2005) Massive infection and loss of memory CD4 þ Tcells in multiple tissues during acute SIV infection. Nature, 434, 1093–1097. D. and Ahmed, R. (1998) Viral immune evasion due to persistence of activated T cells without effector function.

Subunit vaccines at this level are composed of secreted antigens and novel adjuvants which are capable of stimulating Tcells. Recombinant BCG vaccines overexpress mycobacterial antigens and/or are endowed with improved immunogenicity. All of these vaccines are aimed at pre-exposure vaccination of a na€ıve target population. 0, the vaccines are aimed at eradicating Mtb; these are combination vaccines that are given either pre- or post-exposure. The target population of latently infected individuals comprises two billion people; post-exposure vaccines for this target population are focused on latency antigens.

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